If coadministration of CYP3A4 inhibitors with fentanyl is essential, observe patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until finally stable drug effects are obtained.If coadministration of CYP3A4 inhibitors with fentanyl is essential, observe patients for respiratory depression an

ribociclib will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Furthermore, fentanyl rapidly crosses the blood-brain barrier, causing greater analgesic potency, that is mirrored in a very half-life of ~5 min for equilibrium between plasma and cerebrospinal fluid. Therefore, the increased analgesic p